Marked reduction of blood pressure with possible development of reflex tachycardia and excessive peripheral vasodilation (there is a probability of occurrence of severe and persistent hypotension, including the development of shock and death).
Treatment: the appointment of activated carbon (especially in the first 2 hours after the overdose), gastric lavage (in some cases), giving the sublime position of the limbs, the active maintenance of the cardiovascular system, winstrol v monitoring indicators of the heart and lungs, the control of blood volume and diuresis .
To restore vascular tone and blood pressure, unless contraindicated, can be useful the use of vasopressors. Use intravenous calcium gluconate. Because amlodipine largely bound to serum proteins – hemodialysis is not effective.
INTERACTION WITH OTHER DRUGS
It can be expected that inhibitors of microsomal oxidation will increase the concentration of amlodipine in the plasma, increasing the risk of side effects, and inducers of microsomal liver enzymes – decrease.
Cimetidine: while the use of amlodipine with cimetidine pharmacokinetics of amlodipine is not changed.
Grapefruit Juice: simultaneous single dose of 240 ml of grapefruit juice and 10mg amlodipine inside is not accompanied by a significant change in the pharmacokinetics of amlodipine.
Unlike other BCCI clinically significant interaction between drug Norvasc (III generation BCCI) was not detected when combined with non-steroidal anti-inflammatory drugs (NSAIDs), especially indomethacin.
Perhaps strengthening anti-anginal and anti-hypertensive action BCCI when combined with thiazide and “loop” diuretics, verapamil, ACE inhibitors, beta-blockers and nitrates , as well as increase their hypotensive effect when combined with alpha 1-blockers, antipsychotic drugs. Although the study Norvasc drug negative inotropic effect is usually not observed, however, some BCCI may increase the severity of the negative inotropic effects of antiarrhythmic drugs causing prolongation of the interval QT (such as amiodarone and quinidine).
In a joint application with the BCCI lithium preparations (for Norvasc no data) may increase their neurotoxicity symptoms (nausea, vomiting, diarrhea, ataxia, tremor, tinnitus).
Amlodipine does not affect the extent of in vitro binding to plasma proteins digoxin winstrol v fenigoina, warfarin and indomethacin .
Aluminium / Magnesium-containing antacids: their single dose had no significant effect on the pharmacokinetics of amlodipine.
Sildepafii (viagra): a single intake of 100 mg of sildenafil in patients with essential hypertension has no impact on the pharmacokinetic parameters of amlodipine.
Atorvastatin: re-administration of amlodipine 10 mg and atorvastatin 80 mg is not accompanied by significant changes in pharmacokinetic parameters of atorvastatin.
Digoxin: while the use of amlodipine with digoxin in healthy volunteers serum levels and renal clearance of digoxin are not changed.
Ethanol (alcoholic beverages) in single and repeated administration at a dose of 10 mg of amlodipine had no significant effect on the pharmacokinetics of ethanol.
Warfarin: amlodipine does not affect the prothrombin time changes caused by warfarin.
Cyclosporine: amlodipine does not cause significant changes in the pharmacokinetics of cyclosporine.
In the treatment of hypertension Norvasc may be used in combination with thiazide diuretics, alpha and beta blockers, ACE inhibitors, long-acting nitrates, sublingual nitroglycerin, NSAIDs, antibiotics and oral hypoglycemic agents.
For the treatment of angina Norvasc may be administered as monotherapy or in combination agent with other antianginal drugs, including in patients refractory to treatment with nitrates and / or beta-blockers in adequate doses. Norvasc did not appear to have any adverse effect on the metabolism of lipids and blood plasma and can be used in the treatment of patients with asthma, diabetes and gout.
Norvasc may be applied in those cases when the patient is predisposed to vasospasm / vasoconstriction.
Patients with low body weight, patients with a short and patients with severe hepatic impairment may need a smaller dose. During treatment requires monitoring of body weight and seeing the dentist (to prevent soreness, bleeding and gingival hyperplasia).
The impact on the winstrol v ability of the car and use the control appliances
Although while taking Norvasc any negative impact on the ability to drive a motor vehicle or other technical means not observed, however, due to the possible excessive reduction in blood pressure, development of dizziness, sleepiness, etc. side effects should be attentive to the individual action of the drug in these situations, especially at the beginning of treatment and when changing the dose regimen. steroids for sale