- Since there is currently no sufficient data on the experience of the use of ritonavir in pregnant women, its function in these patients is only possible when the expected benefit to the mother outweighs the potential risk to the fetus. The data on the excretion of the drug in breast milk have no women. HIV-infected women should not breast-feed their children, in order to avoid transmission of winstrol side effects. Inside during meals. Adults: . 600 mg (6 tablets) twice daily tablets must be swallowed whole and must not chew, crush or grind. A gradual increase in dose in the initial period of treatment may contribute improve drug tolerability. The initial dose is at least 300 mg twice a day for the first 3 days, then dose increased to 100 mg 2 times a day up to 600 mg two times a day for a period not exceeding 2 weeks. Should not continue treatment with in a dose of 300 mg two times a day over three days.
Combined schemes with two treatments of HIV protease inhibitors (PI): Clinical experience dual therapy comprising the use of therapeutic doses of ritonavir in combination with another HIV protease inhibitor, is limited. Therefore, when assigning dual therapy with ritonavir should take into account the pharmacokinetic interaction and safety data used drugs. For this class of drugs is characterized winstrol before after by severe cross-resistance. Provision should be made use of a combination of two SP with the lowest cross-resistant. When using ritonavir composed data circuits, these factors should be considered. Adults: Amprenavir 600 mg twice daily with ritonavir 100 mg twice daily; atazanavir 300 mg once daily with ritonavir 100 mg once daily; fosamprenavir winstrol side effects 700 mg twice daily with ritonavir 100 mg twice daily; Lopinavir 400 mg / ritonavir 100 mg (combined form) twice a day saquinavir 1000 mg twice daily with ritonavir 100 mg twice a day ; Darunavir 600 mg twice daily with ritonavir 100 mg twice daily.
Children (3 years and older) should be administered ritonavir in combination with other antiviral medicines. The recommended dose of the drug Norvir ® for children is 350-400 mg / m 2 2 times a day, and it should not exceed 600 mg 2 times a day. The initial dose of 250 mg / m 2 , it should be increased at intervals of 2-3 days at 50 mg / m 2 , 2 times a day. If patients can not tolerate the maximum daily dose for side effects prescribed maximum tolerated dose Norvir ® . In combination with other antiretroviral drugs Body surface area (BSA) can be calculated by the following formula: BSA (m 2 ) = √ ([Height (cm) x weight (kg)] / 3600) elderly patients: dose adjustment is required
Side effects Adults The most frequently in adult patients experienced fatigue, gastrointestinal and neurological disorders, including nausea, diarrhea, vomiting, anorexia, abdominal pain, dysgeusia, paresthesia, perioral and peripheral paresthesia. The following are the side effects reported in clinical studies phase II-III, whose connection with the reception of ritonavir available or is not installed. At 2% or more of patients taking ritonavir, note the following side effects: On the part of metabolism: hyperlipidemia, weight loss. From the nervous system: dizziness, headache, hyperesthesia, paresthesia, drowsiness, anxiety, insomnia. The respiratory system : increased cough, pharyngitis. on the part of the gastrointestinal tract: dry mouth, dyspepsia, belching, bloating, irritation in the throat, ulceration of the mouth. skin and subcutaneous tissue: maculopapular rash, pruritus, rash, sweating. With the musculoskeletal system: myalgia. General disorders: . fever, pain side effects observed in less than 2% of patients in clinical trials II-III phase, whose connection with the reception of ritonavir available or not installed: from the blood and lymphatic system: anemia, ecchymosis, leukopenia, lymphadenopathy, lymphocytosis, and thrombocytopenia. immune system: allergic reactions. On the part of the endocrine system: diabetes. On the part of metabolism: vitamin deficiency, cachexia, dehydration, edema, glycosuria, gout, hypercholesterolemia, peripheral swelling, redistribution / accumulation of body fat in the tissues. From the nervous system: sleep disturbances, amnesia, aphasia, ataxia, seizures, grand mal seizures, incoordination, neuralgia, peripheral sensory neuropathy, paralysis, loss of taste, tremor, disturbance of the visual field, violation of smell, agitation, delirium, depression, emotional lability, euphoria, hallucinations, nervousness, abnormal thinking. On the part of the organ of vision: blurred vision, amblyopia / blurred vision, blepharitis, diplopia, eye pain, iritis, photophobia, uveitis . On the part of the organ of hearing, and the vestibular system: pain in the ears, hearing loss, increased production of earwax, tinnitus and vertigo. On the part of the cardiovascular system: heart rate, fainting, hemorrhage, hypotension, migraine, peripheral vascular disorders, orthostatic hypotension and tachycardia. The respiratory system: asthma, shortness of breath, epistaxis, hiccup, hypoventilation, interstitial pneumonia, pathology of lung and rhinitis.
- From the musculoskeletal system: arthralgia , arthritis, back pain, joint disease, muscle spasms (cramps), muscle weakness, myositis, neck pain, stiffness in the neck winstrol side effects muscles, jerking (tick). On the part of the kidney and urinary tract: dysuria, hematuria, kidney stones, renal insufficiency pain in the kidney, nocturia, polyuria, pyelonephritis, urethritis, frequent urination and urinary retention. On the part of the reproductive system: impotence, decreased libido. General disorders: gait disturbance, chest pain, chills, flu-like symptoms, malaise, pain behind the breastbone, hypothermia. Other: pathological changes in the EOG, electroretinogram, changes in hormonal profile.