The significance of this interaction was confirmed in clinical studies. And may require a greater reduction winstrol reviews in dose. Saquinavir, ritonavir, saquinavir actively inhibits metabolism, which leads to a significant increase in plasma concentrations of the drug.
At the appointed time the combination therapy to 24 weeks with doses of ritonavir or saquinavir 400 mg three times a day, an increase incidence of side effects. Values in the blood plasma exposure achieved when assigning Invirase (hard gelatin capsule saquinavir mesylate) (400 mg, 2 times daily) and RTV (400 mg, 2 times a day) was similar with those identified in the application Fortovase (soft gelatin capsules saquinavir) (400 mg twice daily) and ritonavir (400 mg twice a day). Do not appoint a saquinavir, ritonavir, and rifampicin, due to the risk of severe hepatotoxic effects (which are shown increasing levels of transaminases).
Drugs used in erectile dysfunctionsildenafil: With extreme caution should be prescribed sildenafil in patients receiving ritonavir. When concomitant administration of ritonavir and sildenafil is expected to significantly increase in sildenafil (increase in AUC 11-fold) concentrations, which may lead to an increased risk of side effects associated with the use of sildenafil, including hypotension, syncope, visual changes and prolonged erection.
Tadalafil should be used with caution. Its dose should not exceed 10 mg 1 time in 72 hours and used in strict control of side effects. Generic Levitra: Vardenafil should be used with caution. Its dose should not exceed 2.5 mg 1 time in 72 hours and used in strict control of side effects. Sulfamethoxazole / trimethoprim When concomitant administration of ritonavir at a dose of 50 mg every 12 hours and sulfametoksazona / trimethoprim occurs winstrol reviews sulfametoksazona reduction in AUC by 20% and increase the trimethoprim AUC by 20%. Changes dose sulfametoksazona / trimethoprim while conducting therapy with ritonavir is required.
Theophylline When concomitant administration of ritonavir 500 mg every 12 hours and there is a decrease theophylline theophylline AUC by 43%. You may need to increase the dose of theophylline. Trazodone When concomitant administration of ritonavir and trazodone may experience an increase in concentrations of trazodone. There were side effects such as nausea, dizziness, hypotension and syncope. When trazodone concurrently with an inhibitor of CYP3A4, such as ritonavir, it should be remembered that this combination should be used with caution and should consider lowering the dose of trazodone. Vincristine, vinblastine When concomitant administration with ritonavir may increase serum concentrations of these drugs, which can . lead to increased incidence of side effects voriconazole When concomitant administration of ritonavir 400 mg every 12 hours have equilibrium values decrease voriconazole average AUC 82%; therefore, co-administration of these drugs is contraindicated (see. “Contraindications”). Warfarin In a pharmacokinetic study of repeated doses of ritonavir appointment (400 mg 2 r / d) has a different effect on the pharmacokinetics of warfarin enantiomers. Changes in the values of AUC S-warfarin were not statistically significant, but under the influence of ritonavir are subject to significant fluctuations. When concomitant administration of ritonavir was observed reduction in AUC less active R-enantiomer of warfarin by an average of 33%.
Associated with these changes, the effect of ritonavir on the anticoagulant effect of warfarin on the basis of pharmacokinetic data is difficult to predict. At the beginning of the simultaneous use of ritonavir and warfarin shown holding frequent monitoring of INR (international non-proprietary relations). ZidovudineWhen concomitant administration of ritonavir 300 mg every of zidovudine respectively 27% and 25%. Conversely, on the pharmacokinetics winstrol reviews of ritonavir has been revealed a very weak effect, or it is completely absent. Changes dose AZT while conducting therapy with ritonavir is required. Table 1Changes in AUC and Cmax values, while the appointment of ritonavir with other medications