Due to the presence winstrol pills of a wide therapeutic range of clarithromycin in patients with normal renal function dose reduction is required.
By comparing the historical data, it was concluded that the pharmacokinetics of delavirdine influenced ritonavir does not change. When concomitant administration with delavirdine should consider lowering the dose of ritonavir. Desipramine When concomitant administration of ritonavir 500 mg every 12 hours and a single dose of desipramine 100 mg is an increase in AUC of desipramine by an average of 145%. Patients receiving this combination of drugs, it is necessary to consider the need to reduce the dose of desipramine. Didanosine has been shown in pharmacokinetic study, that while the appointment of ritonavir 600 mg every 12 hours and didanosine (DTT) at a dose of 200 mg every 12 hours is a decrease equilibrium values of Cmax and AUC DTTs by 16% and 13%, respectively. Conversely, to the pharmacokinetics of Ritonavir it revealed very little effect, or it was not detected at all. Changes dose DTT while the appointment with ritonavir is not required; however, the interval between doses of doses of these two drugs must be at least 2.5 hours in order to avoid incompatibility. Digoxin Co-administration of ritonavir (300 mg, 2 times daily) and digoxin leads to a significant increase in the levels of digoxin. When concomitant administration of ritonavir and digoxin should be careful and conduct appropriate monitoring of serum digoxin levels.
Efavirenz In healthy volunteers receiving 500 mg of ritonavir twice daily and efavirenz 600 mg once daily, the equilibrium values of AUC of efavirenz increased by 21%. At the same time there was an increase in AUC of ritonavir, 17% of fluticasone propionate When concomitant administration of ritonavir and fluticasone propionate may increase concentrations of the latter. This combination should be administered with caution. Consider the appointment of alternate fluticasone propionate products, especially when long-term therapy. Fusidic acid When concomitant administration of HIV protease inhibitors, including ritonavir, and fusidic acid is expected to increase fusidic acid levels, as well as an increase in plasma concentrations of HIV protease inhibitors.
Drugs Hypericum perforatum Patients taking ritonavir simultaneously use contraindicated drugs containing St. John’s wort (Hypericum perforatum), as this may increase the plasma concentrations of ritonavir. This effect may be associated with the induction of CYP3A4 and may reduce the therapeutic efficiency and development of resistance to ritonavir indinavir, ritonavir inhibits the metabolism of indinavir, which is carried by CYP3A. In healthy individuals the appointment ritonavir at a dose of 200 to 400 mg twice from 400 to 600 mg increase in AUC indinavir was observed from 185 to 475% per day simultaneously with a single dose of Indinavir, Cmax – from 21 to 110% and C min – in 11-33 times in comparison with the same values when assigning indinavir fixed dose of 400 to 600 mg in the form of monotherapy.
The data on the efficacy and safety winstrol pills of these drug combinations are limited in patients. In the appointment of indinavir 800 mg twice a day or more in combination with ritonavir may increase the risk of nephrolithiasis. Recommended hydration and adequate control of these patients.
Methadone When concomitant administration of ritonavir with methadone is expected to decrease methadone concentrations. You may need to increase the dose of methadone. Nelfinavir: Interactions between ritonavir and nelfinavir is probably associated with both inhibition and induction of a P450. When concomitant administration of ritonavir 400 mg twice a day, a statistically significant increase in the concentrations of M8 (major active metabolite of nelfinavir) and the slight increase in concentrations of nelfinavir. In a study of 10 patients in the appointment nelfinavir 750 mg and ritonavir 400 mg twice a day were obtained somewhat higher values . AUC value for M8 increased by 347%. Oral Contraceptives and contraceptive patches Co-administration of ritonavir at a dose of 500 mg every 12 hours and an oral contraceptive in fixed combination can reduce the mean winstrol pills respectively. It is necessary to consider the possibility of increasing the dose of oral contraceptives or contraceptive patch containing ethinyl estradiol, or the use of alternative methods of contraception. Rifabutin has been shown in pharmacokinetic study, that the co-administration of ritonavir 500 mg every 12 hours and rifabutin results in an increase in AUC values of 4-35 times for rifabutin and its active metabolite 25-O-deatsetilrifabutina respectively.