The active ingredient nootropics Piracetam is a cyclic derivative of gamma-aminobutyric acid (GABA). Piracetam is a nootropic agent that acts directly on the brain, improving cognitive (cognitive) processes, such as learning ability, memory, attention and mental performance. Nootropil affects the central nervous winstrol for sale system in different ways: changing the speed of propagation of excitation in the brain, improving metabolic processes in nerve cells; improving microcirculation by acting on the rheological properties of blood and causing vasodilatory action. Improves communication between the hemispheres of the brain and synaptic conductance in neocortical structures, it improves mental performance, improves cerebral blood flow.
Piracetam inhibits platelet aggregation and restores elasticity of the erythrocyte membrane, reduces adhesion of red blood cells. At a dose of 9.6 g reduces fibrinogen and Villibranta factors, 30% -40% and prolongs bleeding time.
Piracetam has a protective effect, improves disturbed as a result of hypoxia and intoxication of the brain function.
Piracetam reduces the severity and duration of vestibular nystagmus.
When receiving the drug inside Piracetam is rapidly and almost completely absorbed, the peak concentration is achieved within 1 hour after administration. The half-life of the drug from plasma was 5.4 hours and 8.5 hours from the cerebrospinal fluid, which is elongated in renal failure. It penetrates the blood-brain and placental barriers and membranes used in hemodialysis. In animal studies piracetam selectively accumulates in the brain cortex tissues, mainly in the frontal, parietal, and occipital lobes, cerebellar and basal ganglia. It binds to plasma proteins, not metabolized in the body and excreted by the kidneys unchanged. 80-100% piracetam excreted by the kidneys unchanged by renal filtration. Piracetam renal clearance in healthy volunteers was 86 ml / min.
– Symptomatic treatment of psycho-organic syndrome, particularly in elderly patients suffering from memory loss, dizziness, decreased concentration and total activity, changes in mood, conduct disorder, gait disorder, as well as in patients with Alzheimer’s disease and senile dementia of the Alzheimer type.
– Treatment effects of stroke, such as speech disorders, disorders of the emotional sphere, to improve motor and mental activity.
– Chronic alcoholism – for the treatment of psycho-organic and withdrawal syndromes.
– The recovery period after the comatose states, including after injuries and cerebral intoxication.
– treatment of vertigo and related balance disorders, with the exception of dizziness and mental vascular origin.
– in the combined therapy of low learning ability in children with psycho-organic syndrome.
– for the treatment of cortical myoclonus as mono- or combination therapy.
– in the treatment of sickle-cell anemia.
– Hypersensitivity of piracetam or pyrrolidone derivatives, as well as other components of the preparation.
– Acute ischemic winstrol for sale stroke (hemorrhagic stroke).
– End-stage renal failure (with creatinine clearance less than 20 ml / min).
– Children under the age of 1 year (for a solution for oral administration, 200 mg / ml), and up to 3 years (capsules and tablets).
Pregnancy and lactation
Animal studies did not reveal any damaging effect on the embryo and its development, including in the postnatal period, and did not change during pregnancy and childbirth.
Studies have not been conducted in pregnant women. Piracetam crosses the placental barrier and into breast milk. The concentration of the drug in infants up to 70-90% of its concentration in the blood of the mother. Except in special circumstances Nootropil should not be administered during pregnancy. It should refrain from breast-feeding in the appointment of a woman piracetam.
Dosage in patients with impaired renal function.
Since winstrol for salel excreted from the body by the kidneys, caution should be exercised when treating patients with renal insufficiency, in line with this dosing regimen.