Dementia moderate and severe Alzheimer’s disease severity. Any component of the formulation, severe hepatic failure, pregnancy, breast-feeding, age and 18 years of age (efficacy and safety have not been studied). Precautions: epilepsy, renal failure, hyperthyroidism, spasms in the anamnesis, hypertension, myocardial infarction history of heart failure.
Memantine has the ability to slow down the development of the fetus. At the time of treatment with memantine breastfeeding should be discontinued.
Dosing and Administration
Inside, regardless of meals.
During the winstrol cycle first week of the daily dose is 5 mg (in the morning). In the second week, the daily dose is 10 mg (5 mg 2 times a day). During the third week, daily dose – 15 mg per day (10 mg in the morning and 5 mg in the evening). From the fourth week of daily intake is 20 mg per day. . The maximum daily dose of 20 mg per day
dose adjustment in elderly patients (over 65 years) is not required.
In moderate renal insufficiency (creatinine clearance 50-80 ml / min) dose adjustment is usually not required; creatinine clearance at 30-49 ml / min initially daily dose does not exceed 10 mg, followed by 7 days provided good tolerance dose can be increased up to 20 mg. In severe renal insufficiency (creatinine clearance 5-29 ml / min) daily dose should not exceed 10 mg.
In mild or moderate hepatic insufficiency (class A and B in Child-Pugh classification) dose adjustment is required.
Side effect On the part of the nervous system: dizziness, headache, drowsiness, gait disturbance, confusion, hallucinations, seizures, psychosis, irritability. On the part of the gastrointestinal tract:constipation; vomiting; pancreatitis, nausea. Infections and infestations: fungal infections. Cardio-vascular system: increased blood pressure venous thrombosis, thromboembolism. On the part of the body as a whole: general weakness, fatigue, allergic reactions.
Overdosing Symptoms: dizziness, tremor, agitation, somnolence, dizziness, agitation, stupor, convulsions, aggression, hallucinations, unstable gait, vomiting, diarrhea. Treatment: gastric lavage, the appointment of activated carbon; symptomatic therapy. No specific antidote.
Interaction with other drugs
When one temporary appointment may weaken the effect of barbiturates and neuroleptics. The action of baclofen and dantrolene can vary floor influence Memantine may therefore be necessary to adjust their dose.
Levodopa effects, dopamine receptor agonists and anticholinergic agents are enhanced by the winstrol cycle simultaneous use of NMDA-antagonists.
Due to the fact that memantine and amantadine are antagonists of NMDA-receptor avoid concurrent use in connection with the risk of toxic effect. Potentially toxic is also a combination of memantine with ketamine, dextromethorphan and phenytoin.
For transport amantadine, cimetidine, ranitidine, quinidine, in the body of quinine and nicotine use the same renal cationic system, it may cause the interaction of these drugs with memantine leading to an increase in its plasma concentrations.
with simultaneous use of memantine hydrochlorothiazide may decrease serum levels.
while the use of warfarin and other indirect anticoagulants require close monitoring of the prothrombin time and international normalized ratio.
In alkaline urine reaction requires more careful monitoring of these patients due to the slow elimination of memantine.
It is known that Alzheimer’s disease affects the ability to drive a vehicle; in addition, winstrol cycle memantine treatment may also alter the rate of reaction, which should be considered in driving and dangerous machinery.