Norilet quickly, but not completely (20-40%) absorbed after administration, the food slows the absorption of the drug.
Maximum plasma concentration is achieved after 1-2 h and are from 1 to 4 mg / ml in a dose dependent manner. The low value of norfloxacin binding to plasma proteins (10-15%) and high solubility in lipids are responsible for a large amount of the drug distribution and good penetration into tissues and organs (kidney parenchyma, ovaries, fluid seminiferous tubules, prostate, uterus, abdominal organs buy winstrol and small pelvis, bile, breast milk), it crosses the blood-brain barrier and the placenta. To a small extent metabolized in the liver. Excreted by the kidneys by glomerular filtration and tubular secretion.
Within 24 hours from the receipt of 32% of the dose excreted by the kidneys in an unmodified form, 5-8% – in the form of metabolites in the bile is allocated about 30% of the dose.
Treatment of infections caused by the pathogens susceptible to the drug:
– Acute and chronic infections of the urinary tract (urethritis, cystitis, pyelonephritis);
– uncomplicated gonorrhea;
Prevention of infectious diseases in patients with granulocytopenia, prevention of traveler’s diarrhea.
– Hypersensitivity to quinolones,
– hepatic failure,
– deficiency of glucose-6-phosphate dehydrogenase,
– childhood and adolescence (18 years).
Cerebral arteriosclerosis, stroke, epilepsy, epileptic syndrome, renal / hepatic failure.
Dosing and Administration
In the absence of specific instructions, the doctor recommends the following doses: 1 tablet (400 mg) 2 times a day for 1 hour or 2 hours after a meal. The treatment duration of 7 to 14 days, longer treatment is carried out if necessary.
Treatment of chronic bacterial prostatitis is carried out within 4-6 weeks.
Gonorrhoea drug administered a single dose of 800 – 1200 mg or 2 times per day, 400 mg for 3-5 days.
For the prevention of traveler’s diarrhea is recommended to take 400 mg a day for 1 day prior to departure and during the time ti ny (no more than 21 days).
For the prevention of septicemia in neutropenic 400 mg administered two times a day.
To prevent a recurrence of urinary tract infections with frequent exacerbations (4-5 times a year), the drug is prescribed 200 mg 1 time per day for a long time.
Freestyle with impaired renal function at creatinine clearance 20 mL / min correction dosing regime is not required.
When creatinine clearance less than 20 ml / min (serum creatinine level or above 5 mg / 100ml) and patients on hemodialysis, appoint half the therapeutic dose Norileta 2 times a day or a full dose 1 time per day.
Side effect From the digestive system: loss of appetite, bitter taste in the mouth, nausea, vomiting, abdominal pain, diarrhea, pseudomembranous enterocolitis (with prolonged use), increased activity of “liver” transaminases.
From the urinary system: crystalluria, glomerulonephritis, dysuria, polyuria, albuminuria, urethral bleeding, gipsrkreatininemiya.
From the nervous system: headache, dizziness, fainting, insomnia, hallucinations ..
Cardio-vascular system: tachycardia, arrhythmias, lowering blood pressure, vasculitis.
Allergic reactions: itching, hives, swelling, malignant exudative erythema (Stevens-Johnson syndrome)
From the musculoskeletal system: arthralgia, tendinitis, tendon rupture.
From the hematopoietic system: eosinophilia, leukopenia, decreased hematocrit.
In case of overdose, you may buy winstrol experience the following symptoms: dizziness, nausea, vomiting, drowsiness, “cold” sweat, puffy face without major changes in hemodynamic readings.
Treatment: gastric lavage, adequate hydration therapy with forced diuresis. It requires inspection and observation in the hospital for several days.
No specific antidote.
The interaction with other drugs
With simultaneous use of norfloxacin and theophylline should monitor the concentration of theophylline in the plasma and adjust the dose, as norfloxacin reduce theophylline clearance to 25%, and may be a corresponding development of unwanted side effects.
It reduces the effect of nitrofurans.
Norfloxacin may enhance the therapeutic effect of cyclosporine and warfarin. in some cases, the use of cyclosporine with norfloxacin was observed increase in serum creatinine concentration, so in these patients is necessary to monitor this indicator. Concomitant use of norfloxacin and antacids containing aluminum or magnesium gidrokid, as well as preparations containing iron, zinc, sucralfate reduces the absorption of norfloxacin (the interval between their intake should be at least 4 hours).
The simultaneous use of drugs, which reduce the seizure threshold, may lead to the development of epileptiform seizures. Simultaneous treatment with norfloxacin drugs have the potential ability to lower blood pressure, it can cause a sharp decline. Therefore, in such cases, as well as simultaneous administration with barbiturates and other drugs for general anesthesia should monitor heart rate, blood pressure and ECG.
During treatment norfloxacin patients should receive a sufficient amount of fluid (under the control of diuresis).
During therapy may increase the prothrombin index (during surgery should monitor the status of the blood coagulation system).
During treatment with norfloxacin should avoid exposure to direct sunlight.
When the pain in the tendons, or the first signs of tenosynovitis recommend repeal the drug.
Effects on ability to drive vehicles and management mechanisms:
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