Excretion of conjugated metabolites – through the intestine (40%) and kidneys (60%). Decrease anavar vs winstrol in serum norethisterone carried out in two phases. The half-life in the first phase lasts for 2.5 hours in the terminal phase -. 80% for 8 hours produced in the liver metabolites excreted by the kidneys.
Puberty, hypersensitivity to the drug, breast cancer (including the suspect), malignant tumors of the female genital organs, pregnancy (including the suspect, except in the case of application over the miscarriage), jaundice (including .ch. history), acute liver disease (including benign and malignant tumors), abnormal liver and kidney function, hyperbilirubinemia, propensity to thrombosis, acute tromboflefit or thromboembolism, bleeding from urinary tract of unknown origin, bleeding from the genital tract of unknown origin, cholestatic jaundice or pregnancy pruritus history, obesity, herpes. Precautions – Bronchial asthma, chronic heart failure, epilepsy, hypertension, migraine, kidney failure, seizures, or other disorders of the central nervous system (incl. . history), diabetes, liver disease (history), hyperlipidemia, history of thrombophlebitis, thromboembolism.
Pregnancy and lactation.
If pregnancy is not used.
The drug has no teratogenic effects, including cardiac and limb development. If you accidentally taking the drug during early pregnancy
Admission norethisterone postpartum reduces the secretion of milk and changes its quality indicators.
Headache, tension mammary glands, dyspeptic symptoms (nausea, vomiting), acyclic bleeding from the vagina, paresthesia, weight gain, fatigue (does not require anavar vs winstrol additional treatment), peripheral edema, allergic reactions (rash, pruritus) . With prolonged use – thrombosis, thromboembolism. . An overdose
may be nausea, vomiting; vaginal bleeding.
Treatment is symptomatic.
Inductors of hepatic enzymes accelerates metabolism of norethisterone. With caution is prescribed concurrently with hypoglycemic drugs, oral anticoagulants, corticosteroids. Not recommended combined with barbiturates, phenytoin, rifampin, cimetidine and other drugs that affect the microsomal oxidation in the liver.
It is necessary before treatment to exclude the presence of malignant tumors, to conduct a preliminary thorough gynecological, oncological examination and examination of the breast.
If the patient has forgotten to take the next tablet, the missed tablet should be taken as soon as possible, and in this case it is necessary to use additional methods anavar vs winstrol of contraception. The action of the drug on the ability to drive and mechanisms, work on which is connected with an increased risk of injury: Norethisterone has no effect on the ability to drive and use machines.